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A family of bipolar disorder with the S1535L mutation of the PCLO gene. (A) The pedigree shows the dominant inheritance of bipolar disorder in this family. (B) Chromatograms show the wild-type G homozygote at the nucleotide position 82585665 of the unaffected mother’s PCLO gene. Simultaneously, both of the affected sisters carried the same G-to-A heterozygous mutation of the PCLO gene.
