Table 1.

Activities of compounds 1, 6–8, 12–14, 17–22, 36–39, 50, 51 and 54–56 against P. falciparum NF54 and L-6 cells, expressed as IC₅₀ (µM) ^a.

Compound	P.f. NF54 b IC50 (µM)	S.I. = IC50 (Cyt.)/IC50 (P.f. NF54)	Cytotoxicity L-6 Cells IC50 (µM)
1	0.4134	316.9	131.0
6	1.012	127.1	128.3
7	3.738	30.22	113.0
8	1.146	62.93	73.00
12	9.325	21.71	202.5
13	1.902	9.043	17.20
14	21.28	6.080	129.4
17	2.533	10.72	27.12
18	6.585	4.829	31.80
19	0.6172	299.7	185.0
20	2.890	12.01	34.72
21	15.64	2.265	35.43
22	2.300	8.770	20.17
36	3.297	37.58	124.0
37	0.2690	461.0	124.0
38	3.174	24.61	78.00
39	0.5795	171.9	99.62
50	51.49	2.026	104.3
51	55.85	2.328	130.0
54	1.222	151.4	184.7
55	4.662	19.27	89.81
56	0.6593	288.6	190.3
CQ	0.009	9672	90.92
POD			0.012

CQ = chloroquine; POD = podophyllotoxin. ^a Values represent the average of four determinations (two determinations of two independent experiments); ^b sensitive to chloroquine.