Table 2.
Risk of clinical outcomes in patients with predialysis advance CKD comparing aspirin Users vs. Nonusers.
| Clinical Outcomes | Before Matching | After Matching | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aspirin Users (n = 3021) |
Aspirin Nonusers (n = 88,723) |
Aspirin Users vs. Nonusrs | Aspirin Users (n = 3021) |
Aspirin Nonuser (n = 9063) |
Aspirin Users vs. Nonusrs | |||||||
| Events | IR | Events | IR | Crude HR (95%CI) |
p Value | Events | IR | Events | IR | HR (95%CI) |
p Value | |
| Dialysis | 2616 | 64.0 | 74,777 | 49.8 | 1.23 (1.18–1.28) | <0.001 | 2616 | 64.0 | 7769 | 53.2 | 1.15 (1.10–1.21) | <0.001 |
| Dead before dialysis |
228 | 5.6 | 5344 | 3.6 | 1.49 (1.30–1.70) | <0.001 | 228 | 5.6 | 535 | 3.7 | 1.46 (1.25–1.71) | <0.001 |
| All-cause Hospitalization | 2427 | 37.5 | 70,969 | 33.7 | 1.12 (1.07–1.16) | <0.001 | 2427 | 37.5 | 7373 | 35.1 | 1.06 (1.02–1.11) | 0.009 |
| GI bleeding | 640 | 8.9 | 19,683 | 8.1 | 1.10 (1.01–1.19) | 0.021 | 640 | 8.9 | 2027 | 8.5 | 1.05 (0.96–1.15) | 0.280 |
| Ischemic stroke | 100 | 1.2 | 2905 | 1.0 | 1.16 (0.95–1.42) | 0.141 | 100 | 1.2 | 290 | 1.0 | 1.15 (0.92–1.45) | 0.217 |
| ICH | 102 | 1.2 | 2883 | 1.0 | 1.20 (0.98–1.46) | 0.073 | 102 | 1.2 | 278 | 1.0 | 1.23 (0.98–1.55) | 0.071 |
| All-cause mortality | 1460 | 19.0 | 32,706 | 13.2 | 1.51 (1.43–1.59) | <0.001 | 1460 | 19.0 | 3557 | 12.4 | 1.37 (1.29–1.45) | <0.001 |
| MACE | 2351 | 27.9 | 58,956 | 20.7 | 1.29 (1.24–1.35) | <0.001 | 2351 | 27.9 | 6613 | 26.6 | 1.15 (1.10–1.20) | <0.001 |
Abbreviation: IR: Incidence rate; PY: Person-year; Rate incidence per 100 PYs, HRs: Hazard ratio; CKD: chronic kidney disease; CI: confidence interval; GI: gastrointestinal; ICH, Intracranial hemorrhage; MACE: major adverse cardiac event.