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NAD+ structure (A) and biosynthetic pathways in mammalian cells (B). 3-HK: 3-Hydroxyl-Kynurenine; 3-HAA: 3-Hydroxyl-Anthranillic Acid; AMS: α-aminomuconate semialdehyde; MNAM: methyl-nicotinamide; NAR: Nicotinic Acid Riboside; NNMT: Nicotinamide N-methyltransferase; PA: Picolinic Acid; Pnp: Purine Nucleoside Phosphorylase; PRPP: Phosphoribosyl pyrophosphate.
