Table 1.

Genetic Risk Assessment in Ovarian Cancer (GRACE) inclusion and exclusion criteria.

Study Participants
Inclusion Criteria	Exclusion Criteria
Female sex in EHR. One of the following ICD-O codes documented between 2008 and 2019: ○C481 Peritoneum, specified parts; ○C482 Peritoneum, NOS; ○C569 Ovary; ○C570 Fallopian tube. No evidence of prior genetic testing in the EHR or prior genetic testing for BRCA1/2 only with a negative result or variants of uncertain significance (VUS). Must have available pathology tissue at a KPNW or KPCO affiliated hospital from resection/excision or have a biobanked sample if the patient is too sick to provide consent, in hospice care, or deceased or be living and able to submit a saliva sample. Age 18 years or older. Patient needs to be a KPNW or KPCO member at the time of ovarian cancer diagnosis. The patient does not need to be a current KPNW or KPCO member. Available personal representative to provide consent for testing of the patient’s pathology tissue or biobanked sample if the patient is too sick to provide consent or in hospice care or deceased.	Prior diagnosis of a hereditary cancer syndrome. Not a KPNW or KPCO member at the time of diagnosis. Unable to consent in English (KPCO only). Unable to provide informed consent. Opted out of research activities.
Cascade testing
Inclusion criteria	Exclusion criteria
First or second degree relative of a study participant with a pathogenic or likely pathogenic variant. Age 18 years or older at the time they are approached for testing.	Known carrier of the same variant identified in the patient. Unable to consent in English (KPCO only).