Akt	protein kinase B
APAF1	apoptotic protease activating factor 1
APC	adenomatous polyposis coli
BAX	BCL2-Associated X Protein
Bcl-xL	B-cell lymphoma-extra large
BCL2	B-cell Lymphoma 2
BRAF	proto-oncogene, serine/threonine kinase
c-Jun	avian Sarma virus-17 oncogene (Jun comes from Japanese JU-NANA)
c-Myc	cellular homologue of avian myelocytomatosis virus
CASP3	caspease-3
CASP8	caspease-8
CASP9	caspease-9
CB	candidate biomarker
CC3	Cleaved Caspase-3
CDK-p21	Cyclin-Dependent Kinase Inhibitor 1
CDK-p72	Cyclin-Dependent Kinase Inhibitor 1B
CDK4	cyclin-dependent kinase 4
CI	combinational index
cIAP1	cellular inhibitor of apoptosis protein-1
cIAP2	Baculoviral IAP Repeat-Containing Protein 3
CIN	Chromosomal Instability
COX-2	Cyclooxygenase 2
CRC	colorectal carcinoma
CRISPR	clusters of regularly interspaced short palindromic repeats
CXCR-4	C-X-C chemokine receptor type 4
Cyt c	cytochrome complex
DCC	deleted in colorectal carcinoma
DR	death receptor
EGFR	epidermal growth factor receptor
EMT	epithelial–mesenchymal transition
ERKs	extracellular signal-regulated kinases
FAP	Familial Adenomatous Polyposis
FCC	Familial Colorectal Cancer
FOLFIRI	folinic acid, fluorouracil and irinotecan
GADD45	Growth Arrest and DNA Damage-inducible
GDT	Gamma-Delta Tocotrienol
HDI	Human Development Index
HIF-1α	hypoxia-inducible factor 1-alpha
HME	High MYC Expression
HMGCR	HMG-CoA reductase
HNPCC	Hereditary Non-Polyposis Colorectal Cancer
hTERT	human telomerase reverse transcriptase
IC50	half maximum inhibitory concentration
ICAM-1	intercellular adhesion molecule 1
IL-8	interleukin-8
KEGG	Kyoto Encyclopedia of Genes and Genomes
KO	Knockout
KRAS	Kirsten rat sarcoma viral oncogene homolog
LEF	lymphoid enhancer-binding factor
LME	low MYC Expression
LNM	lymph node metastasis
MCRC	metastatic colorectal cancer
miRNAs	micro-ribonucleic acids
MLH1	MutL homolog 1
MMP-7	Matrix metalloproteinase-7 or Matrilysin
MMP-9	Matrix Metallopeptidase 9
MSH2	MutS homolog 2
MSI	Microsatellite Instability
MSI-H	Microsatellite Instability High-Frequency
MSI-L	Microsatellite Instability Low-Frequency
NF-κB	nuclear factor kappa-light-chain-enhancer of activated B cells
OS	overall survival
p-value	calculated probability
p38 MAPK	p38 mitogen-activated protein kinases
p53	tumor suppressor protein (MW = 53 kD)
PARP-1	poly [ADP-Ribose] polymerase 1
PFS	progression-free survival
PKC	protein kinase C
PPI	protein-protein interaction
PRISMA	preferred reporting items for systematic reviews and meta-analyses
RhoA	transforming protein
Ser473	serine kinase
SMAD4	such as mothers against decapentaplegic homolog 4
T3s	tocotrienols
TBE	TCF4/LEF Binding Elements
TCF	T-cell factor
TCF4	Transcription Factor 4
TGF-RII	transforming growth factor receptor II
Thr308	threonine kinase
TRAIL	tumor Necrosis Factor-Related Apoptosis-Inducing Ligand
TRF	tocotrienol-rich fraction
TSG	tumor suppressor genes
TT	target therapy
VEGF	vascular endothelial growth factor
VEGFA	vascular endothelial growth factor A
Wnt	Wingless-related integration site
Wnt-1	Wingless-related integration site-1
αToc	alpha-tocopherol
γT3	gamma-tocotrienol
δT3	delta-tocotrienol