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ARG2 activity is central to different pathways in human metabolism. ARG2 is involved in the biosynthesis of polyamines, glutamate, proline, creatine, agmatine, nitric oxide and citrulline. NOS, nitric oxide synthase; ARG2, arginase 2; ODC1, ornithine decarboxylase 1; GATM, glycine amidinotransferase; ADC, arginine decarboxylase; OAT, ornithine aminotransferase; ALDH4A1, aldehyde dehydrogenase 4 family member A1; PYCR3, pyrroline-5-carboxylate reductase 3.
