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. 2021 Oct 30;13(11):3904. doi: 10.3390/nu13113904

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Vigeo attenuates receptor activator of nuclear factor-B ligand (RANKL)-induced osteoclast differentiation without cytotoxicity. (A) Bone marrow macrophages (BMMs) were cultured with 30 ng/mL M-CSF and the indicated concentration of Vigeo for 3 days. Cell viability of Sec was evaluated using the XTT assay by measuring absorbance at 450 nm. (B) BMMs were seeded with M-CSF (30 ng/mL) and stimulated with RANKL (100 ng/mL) and the indicated concentrations of Vigeo for 3 days. TRAP staining was performed to assess osteoclast formation and representative images were captured. (C) TRAP-positive multinucleated cells counted as osteoclasts (nuclei > 5). *** p < 0.001 versus the control group.