Table 1.

Quantitative studies on the effect botulinum neurotoxins on sebum secretion in patients with facial seborrhea.

First Author	Product	Injection	n	Findings (As Described in the Paper)
Min [32]	ONA	IM	42	A significant decrease in sebum production A sebum gradient surrounding the injection point No difference in the efficacy between the 10 units group and the 20 units group Recovery of the sebum production at the 16-week follow-up
Kondrateva [33]	ONA	IM	15	Maximum decrease in sebum production at the 4-week follow-up A return-to-baseline at 16 weeks after injection
Hathout [30]	ONA	ID	20	A significant decrease in sebum production Patient satisfaction up to 3 months Associated improvement in the skin tone and facial pores No influence of age, gender, or skin types
Shirshakova [31]	ONA	ID	12	A decrease of skin surface sebum amount at 1 week and 2 weeks after injection
Li [19]	MTX	ID	20	A marked decrease in sebum production on the BoNTA-treated side in facial seborrhea group
Rose [2]	ABO	ID	25	A significantly lower sebum production at 1, 4, 8, and 12 weeks after injection
Kesty [34]	ABO	ID	50	A significant decrease in sebum production in the treatment groups 30 units and 45 units The effect lasted for 6 months after injection

ABO: abobotulinumtoxinA (Dysport; Ipsen, Wrexham, UK); ID: intradermal injection; IM: intramuscular injection; MTX: Meditoxin (Medy-Tox Inc., Seoul, Korea); ONA: onabotulinumtoxinA (Botox; Allergan, CA, USA).