Cui 2005.

Methods	RCT
Participants	200 participants with ischaemic stroke Time of randomisation after stroke onset: within 7 days Treatment: 100 participants at randomisation (60% male, mean age 63 years) and 98 for analysis (2 lost to follow‐up) Control: 100 participants at randomisation (56% male, mean age 64 years) and 97 for analysis (3 lost to follow‐up)
Interventions	Treatment: buflomedil hydrochloride (200 mg, daily, 14 days) + control intervention Control: usual medical care or rehabilitation
Outcomes	Time of outcome assessment: by the end of 14‐day treatment and 3‐month follow‐up (after randomisation) Death at 3‐month follow‐up Disability (Barthel Index ≤ 60) at 3‐month follow‐up CSS by the end of treatment Adverse events during treatment
Notes	Funding: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Randomised" but did not report the methods of randomisation
Allocation concealment (selection bias)	Unclear risk	Insufficient information was reported to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Interventions used in the 2 groups were visibly different
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"Blind assessment"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Reported that 2 participants in treatment group and 3 participants in control group lost to follow‐up
Selective reporting (reporting bias)	Unclear risk	The protocol was not available. Insufficient information to permit judgement