Dong 2004.

Methods	RCT
Participants	67 participants with ischaemic stroke Time of randomisation after stroke onset: within 72 hours Treatment (buflomedil + urokinase): 36 participants at recruitment and all completed the trial Control (urokinase): 31 participants at recruitment and all completed the trial
Interventions	Treatment: buflomedil hydrochloride (100 mg, ivgtt, daily, 10 days) + control intervention Control: urokinase (300,000 to 500,000 U, ivgtt, daily, 5 days) + low molecular weight dextran (250 ml, ivgtt, daily, 10 days) + danshen (10 ml, ivgtt, daily, 10 days) + cerebrolysin (10 ml, ivgtt, daily, 10 days)
Outcomes	Time of outcome assessment: 15 days after randomisation (5 days after the end of treatment) Death by the end of treatment CSS Haemorheological indices (whole blood viscosity, plasma viscosity, plasma fibrinogen)
Notes	Combination of buflomedil with urokinase Funding: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Randomised" but did not report the methods of randomisation
Allocation concealment (selection bias)	Unclear risk	Insufficient information was reported to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Interventions used in the 2 groups were visibly different
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	The trial did not address this outcome
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	High risk	Data for some haemodynamic measures listed in the Methods section were not reported in the Results section (e.g. haematocrit)