Guo 2010.

Methods	RCT
Participants	206 participants with ischaemic stroke (54% male, mean age 66 years) Time of randomisation after stroke onset: mean = 14 hours, SD = 2 hours Treatment: 103 at randomisation and all completed the trial Control: 103 at randomisation and all completed the trial
Interventions	Treatment: buflomedil (100 mg, ivgtt, daily, 14 days) + control intervention Control: sodium ozagrel (80 to 160 mg, ivgtt, daily, 14 days) + usual medical care
Outcomes	Time of outcome assessment: by the end of 14‐day treatment CSS
Notes	Combination of buflomedil with sodium ozagrel Funding: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Randomised" but did not report the methods of randomisation
Allocation concealment (selection bias)	Unclear risk	Insufficient information was reported to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Interventions used in the 2 groups were visibly different
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	The trial did not address this outcome
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Unclear risk	The protocol was not available. Insufficient information to permit judgement