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. 2015 Jul 20;2015(7):CD009570. doi: 10.1002/14651858.CD009570.pub2

Pan 2007.

Methods RCT
Participants 108 participants with acute ischaemic stroke
Time of randomisation after stroke onset: between 2 hours and 6 days
Treatment: 54 participants at randomisation (52% male, age range 38 to 78 years) and all completed the trial
Control: 54 participants at randomisation (55% male, age range 46 to79 years) and all completed the trial
Interventions Treatment: buflomedil hydrochloride (200 mg, ivgtt, daily, 15 days) + control intervention
Control: batroxobin (DF‐521) (d1: 10 batroxobin units ivgtt, daily; d3: 5 batroxobin units, ivgtt; d5: 5 batroxobin units, ivgtt) + usual medical care
Outcomes Time of outcome assessment: by the end of 15‐day treatment
Death by the end of treatment
CSS
Haemorheological indices (whole blood viscosity, platelet aggregation rate, fibrinogen, platelet count, prothrombin time)
Adverse events
Notes Combination of buflomedil with batroxobin
Funding: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "Randomised" but did not report the methods of randomisation
Allocation concealment (selection bias) Unclear risk Insufficient information was reported to permit judgement
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Interventions used in the 2 groups were visibly different
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk The trial did not address this outcome
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No missing outcome data
Selective reporting (reporting bias) Unclear risk The protocol was not available. Insufficient information to permit judgement