Yang 2012.

Methods	RCT
Participants	94 participants with acute ischaemic stroke Time of randomisation after stroke onset: between 24 hours and 72 hours Treatment: 50 participants at randomisation (54% male, age range 50 to 80 years) and all completed the trial Control: 44 participants at randomisation (34% male, age range 51 to 79 years) and all completed the trial
Interventions	Treatment: buflomedil hydrochloride (150 mg, ivgtt, daily, 14 days) + control intervention Control: xueshuantong (500 mg, ivgtt, daily, 14 days)
Outcomes	Time of outcome assessment: by the end of 14‐day treatment Death by the end of treatment CSS Adverse events
Notes	Combination of buflomedil with xueshuantong Funding: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Randomised" but did not report the methods of randomisation
Allocation concealment (selection bias)	Unclear risk	Insufficient information was reported to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Interventions used in the 2 groups were visibly different
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	The trial did not address this outcome
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Unclear risk	The protocol was not available. Insufficient information to permit judgement