Table 5.

Univariate and multivariate analysis of factors associated with dexamethasone and anti-IL-6 combination treatment

		Dexamethasone and anti-IL-6 treatment	No dexamethasone and anti-IL-6 treatment	Univariate OR (95% CI)	Multivariate OR (95% CI)
Age, years		29; 51·2 (13·3)	480; 59·8 (12·3)	0·95 (0·92–0·98)	0·29 (0·11–0·74)*
Hypertension		28	479	..	..
	Yes	8 (29%)	246 (51%)	..	..
	No	20 (71%)	233 (49%)	0·38 (0·16–0·88)	0·43 (0·19–1·01)†
Solid organ transplantation		29	480	..	..
	Yes	4 (14%)	31 (6%)	..	..
	No	25 (86%)	449 (94%)	2·32 (0·76–7·08)	..
Any immunosuppression		29	480	..	..
	Yes	6 (21%)	49 (10%)	..	..
	No	23 (79%)	431 (90%)	2·30 (0·89–5·91)	..
Duration of mechanical ventilation, days		29; 31·7 (19·3)	479; 26·9 (19·8)	1·01 (0·99–1·03)	..
Simplified Acute Physiology Score II at admission		25; 44·4 (15·2)	460; 44·1 (16·3)	1·00 (0·98–1·03)	..
Sequential Organ Failure Assessment at admission		25; 7·8 (3·6)	373; 7·4 (4·0)	1·03 (0·93–1·14)	..
Death in intensive care unit		29	480	..	..
	Yes	15 (52%)	171 (36%)	..	..
	No	14 (48%)	309 (64%)	1·94 (0·91–4·11)	..
Proven or probable CAPA‡		29	480	..	..
	Yes	8 (28%)	68 (14%)	..	..
	No	21 (72%)	412 (86%)	2·31 (0·98–5·42)	2·54 (1·00–6·43)§
Aspergillus spp in respiratory samples		29	480	..	..
	Yes	9 (31%)	54 (11%)	..	..
	No	20 (69%)	426 (89%)	3·55 (1·54–8·19)	..
pr/pb invasive fungal infection other than pr/pb CAPA		29	480	..	..
	Yes	3 (10%)	35 (7%)	..	..
	No	26 (90%)	445 (93%)	1·47 (0·42–5·09)	..
Candidaemia		29	480	..	..
	Yes	3 (10%)	29 (6%)	..	..
	No	26 (90%)	451 (94%)	1·79 (0·51–6·28)	..

Data are n, n (%), mean (SD), or n; mean (SD). All variables were analysed but only statistically significant variables or variables of interest are presented. IL=interleukin. OR=odds ratio.

^*p=0·0098.

^†p=0·054.

^‡CAPA status according to Koehler et al.⁸

^§p=0·0049.