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. Author manuscript; available in PMC: 2022 Oct 13.
Published in final edited form as: J Am Chem Soc. 2021 Sep 29;143(40):16549–16555. doi: 10.1021/jacs.1c06200

Figure 3.

Figure 3.

(a) The H1′-H6/H8 region and (b) H1–H8 region from the 2D-NOESY spectrum of 2:1:1 berberine–dGMP–vG4 ternary complex in H2O with sequential assignment pathway. Missing connectivities are labeled with asterisks. Condition: 1.5 mM Pu19m2 DNA, 3:1 dGMP/DNA, 2:1 drug/DNA, pH 7, 50 mM K+, 25 °C, mixing time of 300 ms.