Table 3.
Univariate and multivariate analyses for overall survival in the training cohort and validation cohort.
| Variable | Training cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | P value | Univariate analysis | Multivariate analysis | P value | |
| P value | HR (95% CI) | P value | HR (95% CI) | |||
| Age (>65) | 0.298 | 0.781 | ||||
| Gender (female/male) | 0.370 | 0.451 | ||||
| HBV infection (presence) | 0.875 | 0.389 | ||||
| HCV infection (presence) | 0.274 | 0.253 | ||||
| Liver cirrhosis (no/yes) | 0.234 | 0.631 | ||||
| AGR stage | 0.012∗ | 2.295 (1.248-4.221) | 0.008∗ | 0.024∗ | 3.327 (1.349-8.206) | 0.009∗ |
| AKP (U/L) (>135) | 0.031∗ | 3.299 (1.458-7.467) | 0.004∗ | 0.039∗ | 3.409 (1.317-8.825) | 0.012∗ |
| CP grade (A vs. B) | 0.024∗ | 0.245 | ||||
| Tumor number (single, multiple) | 0.485 | 0.466 | ||||
| Tumor size (cm) (≤3, 3–5) | 0.044∗ | 2.002 (1.108-3.974) | 0.047∗ | 0.021∗ | 2.090 (1.223-3.573) | 0.007∗ |
| TB (μmol/L) (≥34) | 0.952 | 0.441 | ||||
| ALT (U/L) (>40) | 0.364 | 0.682 | ||||
| AFP (ng/mL) (>400) | 0.624 | 0.570 | ||||
| ALBI grade (1/2/3) | 0.017∗ | 0.111 | ||||
| AJCC TNM-8 (Ia, Ib, II) | 0.945 | 0.307 | ||||
Abbreviations: HR: hazard ratio; HBV: hepatitis B virus; HCV: hepatitis C virus; AGR: albumin to gamma-glutamyltransferase ratio; AKP: alkaline phosphatase; CP grade: Child-Pugh grade; TB: total bilirubin; ALT: alanine aminotransferase; AFP: alfa-fetoprotein; ALBI grade: albumin-bilirubin grade; AJCC TNM-8: the 8th edition of American Joint Committee on Cancer TNM staging system. ∗Statistically significant.