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. 2022 Jan 12;30(1):53–68.e12. doi: 10.1016/j.chom.2021.11.013

Figure 4.

Figure 4

Overall structures of Beta RBD/Beta S complexes with Beta mAb Fabs reported in this paper

(A) Front and back views of Beta RBD/Beta Fab complexes. Fabs drawn as ribbons with HC red and LC blue, and RBDs as gray surfaces with ACE2 footprint in green, mutation sites of the Beta variant in magenta and Delta variant in orange. All structures were crystallographic except Beta-26 and -32, which were derived by cryo-EM.

(B) Crystal structure of Beta-32 Fab with HC red and LC blue.

(C) Cryo-EM maps of Beta S complexes with Beta-6, -26, -32, -44, -53, -43, -49, and -50 and early pandemic mAb-222 Fabs. The bound Fabs are orange, RBD domains cyan, and the rest of S gray. Arrows indicate the RBD orientations. See also Figure S3 and Tables S2 and S4.