Figure 7.

Details of interactions of Beta-22, -29, -47, -26, -53, and -43

(A) Interactions of Beta-22 (as Figure 6A). N417 specificity is achieved indirectly.

(B) Identical binding modes of Beta-22 (gray) and Beta-29 (HC red, LC blue) IgVH3-30 mAbs.

(C) Beta-44/Beta RDB interactions.

(D) Beta-47/Beta RDB interactions.

(E) Beta-26 binds the left shoulder contacting K484 and T478 of the RBD.

(F) Beta-53 (HC red, LC blue) binds the same epitope as S309 (HC salmon, LC pale blue; PDB: 7BEP).

(G) Binding of Beta-53 relative to ACE2 receptor.

(H) Beta-43 binding to the NTD (gray surface). See also Figure S5.