. Author manuscript; available in PMC: 2021 Nov 27.

Published in final edited form as: J Assoc Nurses AIDS Care. 2020 Jan-Feb;31(1):12–24. doi: 10.1097/JNC.0000000000000152

Table 2.

Relationships Between Biomarkers and Fatigue

	30-Day Average of PROMIS Fatigue T-scores	TSH (ng/dl)	CRP (mg/L)	IL-6 (pg/ml)	MCP-1 (pg/ml)	IGF-1 (ng/ml)
Average fatigue
TSH (ng/dl)	−.09^*
CRP (mg/L)	+.08	−.12
IL-6 (pg/ml)	−.06	−.11	+.02
MCP-1 (pg/ml)	+.01	+.16	−.24	−.02
IGF-1 (ng/ml)	+.32^***	+.17	−.13	+.04	+.11
TNF-R1 (pg/ml)	−.11	+.05	+.39^*	+.22	+.20	−.06

Note. Relationships between biomarkers and daily PROMIS fatigue scores were calculated through univariate multilevel models with the biomarker value as a Level 2 predictor and fatigue scores as a Level 1 outcome variable within persons over time. Relationships between individual biomarkers, each of which was analyzed at only one point in time, were calculated as bivariate Pearson correlation coefficients. CRP = C-reactive protein (high-sensitivity immunoturbidimetric, Beckman Coulter); IGF-1 = insulin-like growth factor-1 (chemiluminescence); IL-6 = interleukin-6 (ELISA, R&D Systems); MCP-1 = monocyte chemoattractant protein-1 (Luminex, R&D Systems); PROMIS = Patient-Reported Outcomes Measurement System; TNF-R1 = tumor necrosis factor receptor-1 (ELISA, R&D Systems); TSH = thyroid-stimulating hormone (immunoenzymatic sandwich, Beckman Coulter).

p< .05

^***

p< .001.