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. 2021 Jul 30;28(12):7012–7021. doi: 10.1016/j.sjbs.2021.07.079

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Histological photomicrographs of the left ventricles (LVs) of all groups of rats. Haematoxylin and eosin (H & E) stain (400 X). A & B: were taken from control and control + ASX-treated rats and show normal architecture with normally sized striated cardiomyocytes that contain central intact nuclei (long arrow) and peripheral endothelial cells (arrowheads), and blood vessels (short arrows). C & D: were taken from LVs of HFD-fed rats and showed abnormal cardiomyocyte structure with increased fiber damage (short arrow), nuclear fading (karyolysis) (long arrow), vacuolization (arrowhead), hypertrophied muscle fibers (thick arrow), an increase in inflammatory cell infiltration (curved arrow). E &F: were taken from LVs of HFD + ASX-treated rats and showed much improvement in the cardiomyocyte structure with intact normally sized muscle fibers that have normal nuclei (long arrow) and endothelial cells (short arrow). However, some muscle fiber damage (arrowhead) and inflammatory infiltration (curved arrow) are still seen. G & H: were taken from HFD + ASX + EX-527-treated rats and showed a similar picture to that seen in HFD-fed rats where cardiomyocytes damage (short arrow), karyolitic nuclei (long arrow), vacuolization (arrowhead) hypertrophied muscle fibers (thick arrow), and increased inflammatory cells infiltration (curved arrow) were abundant.