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. 2021 Jul 30;28(12):7012–7021. doi: 10.1016/j.sjbs.2021.07.079

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Collagen deposition (A-F) and protein levels of some fibrotic genes in the left ventricles (LVs) of all groups of rats. A-F: Masson trichrome stain (400X). The black arrow in A-F indicates the number of college fibers deposited in each LV sample. A & B: were taken from LVs of control and control + ASX-treated rats and showed few collagen fibers. C: was taken from the LV of an HFD-fed rat and showed increased collagen deposition and interstitial fibrosis. D and E: were taken from LVs of HFD + ASX-treated rats and showed a significant reduction in the amount of collagen fiber as compared to HFD-fed rats. F: was taken from LV of HFD + ASX + EX-527-treated rats and showed increased collagen deposition. In G-H: Data were analyzed for n = 6 samples/group and were significantly different p < 0.05. ^a: vs. the control rats; ^b: vs. the control + ASX-treated rats; ^c: vs. HFD-fed rats, ^d: vs. HFD + ASX-treated rats. EX-527: a selective SIRT1 inhibitor.