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Nuclear activity of SIRT1 (A), the nuclear activity of Nrf2 and NF-κB p65 (B), total protein levels of SIRT1 (C), and nuclear protein levels of SIRT1, acetyl Nrf2, and acetyl NF-κB p65 in the left ventricles (LVs) of all groups of rats. Data were analyzed for n = 6 samples/group and were significantly different p < 0.05. a: vs. the control rats; b: vs. the control + ASX-treated rats; c: vs. HFD-fed rats, d: vs. HFD + ASX-treated rats. EX-527: a selective SIRT1 inhibitor.
