Fig. 2.

Anti-proliferative activity of hesperidin and hesperetin in BC cells. A) Effects of hesperidin and hesperetin on associated molecular targets. B) Involvement of AKT and NF-κB signalling pathways in regulation of PD-L1 expression. AKT, Protein kinase B; EMT, Epithelial-mesenchymal transition; GLUT1/4, Glucose transporter type 1/4; GPCRs, G-protein-coupled receptors; HER2, Human epidermal growth factor receptor 2; IKK, IκB kinase; NF-κB, Nuclear factor kappa B; PD-L1, Programmed death-ligand 1; PI3K, Phosphoinositide 3-kinase; RTKs, Receptor tyrosine kinases.