Fig. 1.

a Study methodology and b number of reports identified. Note: One report could contain more than one adverse event reported by the same individual. ^aIdentified with the Medical Dictionary for Regulatory Activities (MedDRA^®) preferred terms listed in ESM 2. ^bIdentified with the MedDRA^® preferred terms listed in ESM 3. ^cExcluded because linked to a co-administered vaccine and not to the adjuvanted recombinant zoster vaccine. ^dReports with unknown time to onset were included among both “possible VZV reactivations” and “vaccination failures.” ^eIncluded suspected and confirmed vaccination failures. ^fDetails on these reports are provided in ESM 6. ^gDetails on these reports are provided in Table 2. AEFI adverse events following immunisation, ESM electronic supplementary material, HZ herpes zoster, LoE lack of efficacy, N total number of reports in a given category, RZV adjuvanted recombinant zoster vaccine, VZV varicella zoster virus