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. 2021 Nov 26;12:6942. doi: 10.1038/s41467-021-27284-7

Fig. 1. DNA modification by the spirocyclopropylcyclohexadienone (SCPCHD) family of natural products.

Fig. 1

a Chemical structures of yatakemycin (YTM), duocarmycin SA (DSA), and CC-1065. All three compounds share the S0 subunit (dark cyan), which includes the reactive SCPCHD moiety, and the S+1 subunit (pale cyan). YTM and CC-1065 also possess the additional subunits S−1 (magenta) and S+2 (green), respectively, on either side of the S0 and S+1 subunits. b Generalized mechanisms of DNA modification by SCPCHD compounds and nucleobase excision by associated DNA glycosylases. c ytk and c10 gene clusters responsible for biosynthesis of YTM and CC-1065, respectively. Genes encoding the DNA glycosylases YtkR2 and C10R5 are colored red.