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. 2021 Nov 26;11:23019. doi: 10.1038/s41598-021-02354-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Hierarchal cluster analysis of metabolites into three patient clusters. Children with and without pediatric acute respiratory distress syndrome (PARDS) are in blue (no PARDS) and in orange (with PARDS). Children with low hypoxemia (no or mild PARDS) are in yellow and those with high hypoxemia (moderate or severe PARDS) are in magenta. Children with no, mild, moderate, or severe PARDS are shown in green from lightest (no PARDS) to darkest (severe PARDS). Children with ventilator-free days (VFD) < 21 days (more than 7 days on a ventilator or death) are in dark purple and those with VFD ≥ 21 days are in light purple. Cluster assignments are denoted by the green (cluster 1), blue (cluster 2), and orange (cluster 3) bar to the left of the participant dendrogram.