Table 2.
Main results of the analysis of variance using polygenic risk score (PRS) for schizophrenia (SZ-PRS) and bipolar disorder (BD-PRS) across the eight studied groups (Table S2 provides the full list of pairwise tests).
| Measure | ANOVA | Means (z-score) | Significant post hoc tests | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sum of squares | df | Mean square | F | p | Group | Mean | SD | Pairwise contrast | Beta | SE | Adjusted p | |
| SZ-PRS | 61.01 | 7 | 8.716 | 9.300 | 2.52 × 10−11 | CTRL | −0.214 | 0.988 | CTRL–SZA | −0.537 | 0.121 | 2.53 × 10−4 |
| SCHIZ L | −0.222 | 0.947 | CTRL–SZ | −0.474 | 0.076 | 1.65 × 10−8 | ||||||
| SCHIZ H | −0.323 | 1.018 | SCHIZ L–SZA | −0.534 | 0.146 | 0.007 | ||||||
| RISK | 0.055 | 0.88 | SCHIZ L–SZ | −0.471 | 0.109 | 4.50 × 10−4 | ||||||
| BD I | 0.036 | 0.986 | SCHIZ H–BD I | −0.388 | 0.112 | 0.015 | ||||||
| BD II | −0.07 | 0.977 | SCHIZ H–SZA | −0.683 | 0.146 | 9.18 × 10−5 | ||||||
| SZA | 0.253 | 0.958 | SCHIZ H–SZ | −0.621 | 0.110 | 5.73 × 10−7 | ||||||
| SZ | 0.243 | 1.012 | BD I–SZ | −0.233 | 0.072 | 0.034 | ||||||
| BD II–SZ | −0.362 | 0.112 | 0.034 | |||||||||
| CTRL–BD I | −0.242 | 0.078 | 0.054# | |||||||||
| SCHIZ H–RISK | −0.394 | 0.129 | 0.064# | |||||||||
| Residuals | 1466.67 | 1565 | 0.937 | |||||||||
| BD-PRS | 76.51 | 7 | 10.930 | 11.709 | 1.37 × 10−14 | CTRL | −0.268 | 0.943 | CTRL–RISK | −0.412 | 0.113 | 0.007 |
| SCHIZ L | −0.222 | 0.993 | CTRL–BD I | −0.558 | 0.078 | 2.86 × 10−11 | ||||||
| SCHIZ H | −0.181 | 0.905 | CTRL–BD II | −0.461 | 0.115 | 0.002 | ||||||
| RISK | 0.230 | 0.905 | CTRL–SZA | −0.572 | 0.12 | 5.99 × 10−5 | ||||||
| BD I | 0.276 | 0.984 | SCHIZ L–RISK | −0.404 | 0.128 | 0.045 | ||||||
| BD II | 0.206 | 0.96 | SCHIZ L–BD I | −0.550 | 0.111 | 2.11 × 10−5 | ||||||
| SZA | 0.213 | 0.971 | SCHIZ L–BD II | −0.453 | 0.140 | 0.033 | ||||||
| SZ | −0.095 | 1.041 | SCHIZ L–SZA | −0.565 | 0.145 | 0.003 | ||||||
| SCHIZ H–BD I | −0.547 | 0.112 | 3.10 × 10−5 | |||||||||
| SCHIZ H–BD II | −0.450 | 0.140 | 0.038 | |||||||||
| SCHIZ H–SZA | −0.561 | 0.146 | 0.004 | |||||||||
| BD I–SZ | 0.351 | 0.072 | 3.12 × 10−5 | |||||||||
| SZA–SZ | 0.365 | 0.117 | 0.050# | |||||||||
| SCHIZ H–RISK | −0.401 | 0.129 | 0.053# | |||||||||
| Residuals | 1460.92 | 1565 | 0.933 | |||||||||
Note: The analyses accounted for age, sex, and the first five genetic ancestry principal components, and statistical significance is indicated by Bonferroni-adjusted p values.
Adjusted p Bonferroni adjusted p value, beta beta coefficient, df degrees of freedom, SE standard error, BD I bipolar I disorder, BD II bipolar II disorder, CTRL controls, RISK at-risk state for psychosis, SCHIZ L lower schizotypy, SCHIZ H higher schizotypy, SZA schizoaffective disorder, SZ schizophrenia.
#Trend toward statistical significance.