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. 2021 Nov 26;11:22996. doi: 10.1038/s41598-021-02040-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PRISMA flow diagram of the search and identification of included studies. Database: PubMed (n = 304), Cochrane Central Register of Controlled Trials (n = 208), Cochrane Database of Systematic Reviews (n = 7). Keyword: (Dementia OR Alzheimer*) AND (acetylcysteine OR α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid OR AMPA OR benzoate OR CX516 OR D-cycloserine OR D-serine OR glutamine OR glutamate OR glutamate carboxypeptidase 2 OR GCP2 OR glycine OR glycine transporter type 1 OR GlyT1 OR glutamate receptor ionotropic kainate OR GRIK OR kynurenine aminotransferase OR KAT OR metabotropic glutamate receptor OR mGluR OR minocycline OR N-acetyl-aspartylglutamate OR NAAG OR N-methyl-d-aspartate OR NMDA OR pregnenolone OR sarcosine) AND controlled trial. Date: date available to August 7th, 2020.