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. 2021 Nov 26;12:6933. doi: 10.1038/s41467-021-27287-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Binary classification of E2 proximity to the E3BP. Proximal E2 monomers are colored green, whereas distal are colored pink. b Violin plot showing the distribution of distances of each E2 to the closest E3BP. Two groups are retrieved: Group 1, in the range of 55 to 70 Å, and Group2, in the range of more than 75 Å. c Enclosure of the backfolded element corresponding to the N-ter region of the E2 at different map contour levels (0.02–0.05). d Number of atoms from the N-ter backfolded element not covered by the cryo-EM map density as a function of applied contour level. The 99% confidence interval (CI) is displayed as dotted lines. e Grouped violin plot showing the probability of additional density to encapsulate the N-ter backfolded element in the two distinct Groups. Group 1 (g1), represents vicinal E2 monomers to E3BPs that have a substantially lower probability to exhibit densities that may cover the N-ter backfolded element. Dashed lines indicate lower and higher quartile and median values.