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. 2021 Nov 26;7:104. doi: 10.1038/s41531-021-00250-2

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© The Author(s) 2021, corrected publication 2022

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Fig. 2 — Fitted curves on the scatter plots were obtained with the RCS model in PPMI (a) (¹²³I-FP-CIT SPECT) and GSH (c) (¹⁸F-FP-CIT PET) cohorts. Outliers beyond the first or third quartile ± 3 × interquartile range (5 putamen, sPD group of PPMI cohort) are not shown. All outliers were included in the calculation of temporal trajectories. Temporal trajectories in the PPMI (b) and GSH (d) cohorts were acquired with a modified Euler’s method for solving the first-order differential equation.