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. 2021 Nov 26;12:6943. doi: 10.1038/s41467-021-27248-x

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Western blotting and quantification of MEGF10 and MERTK protein levels (normalized to corresponding sham) in ischemic (a) and hemorrhagic mouse brain (k). Immunostaining showed MEGF10 (green) and MERTK (green) were expressed in Iba-1⁺ microglia/macrophages (red) and GFAP⁺ astrocytes (red) in ischemic (c–f) and hemorrhagic stroke (m–p). Arrows indicated colocalization of MEGF10 and MERTK with microglia/macrophages and astrocytes. Bar = 50 µm. Fluorescence in situ hybridization study showed MEGF10 (red) and MERTK (red) signals colocalized in Iba-1⁺ microglia/macrophages (green) and GFAP⁺ astrocytes (green) in ischemic (g–j) and hemorrhagic stroke (q–t), indicated by arrows. Bar = 50 µm. (b, l) N = 4 mice per group. (d, f, h, j, n, p, r, t) Statistics are derived from six slices, n = 3 mice per group. Data are mean ± SD.