Table 1:
The Proportion of Mφ/DC Subpopulation in Human Skin
| subject | number of cells | number of Myeloid Cells |
percentage of Macrophages and DCs in all cells |
number of MS4A4A+ Macrophages |
percentage of MS4A4A+ Macrophages in all cells |
number of FCGR3A+ Macrophages |
percentage of FCGR3A+ Macrophages in myeloid cells |
number of FCN1+ cells |
percentage of FCN1+ Cells in myeloid cells |
number of proliferaftiing macrophage |
percentage of proliferating macropahges |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SC1nor | 1488 | 51 | 3.43% | 23 | 1.55% | 0 | 0.00% | 1 | 1.96% | 0 | 0.00% |
| SC4nor | 3887 | 56 | 1.44% | 21 | 0.54% | 4 | 7.14% | 4 | 7.14% | 0 | 0.00% |
| SC18nor | 3183 | 154 | 4.84% | 68 | 2.14% | 1 | 0.65% | 8 | 5.19% | 1 | 0.65% |
| SC32nor | 1956 | 100 | 5.11% | 35 | 1.79% | 0 | 0.00% | 2 | 2.00% | 0 | 0.00% |
| SC33nor | 2156 | 173 | 8.02% | 92 | 4.27% | 0 | 0.00% | 4 | 2.31% | 0 | 0.00% |
| SC34nor | 2118 | 24 | 1.13% | 6 | 0.28% | 2 | 8.33% | 1 | 4.17% | 0 | 0.00% |
| SC50nor | 3670 | 54 | 1.47% | 19 | 0.52% | 0 | 0.00% | 1 | 1.85% | 0 | 0.00% |
| SC68nor | 2116 | 64 | 3.02% | 33 | 1.56% | 4 | 6.25% | 1 | 1.56% | 0 | 0.00% |
| SC124nor | 4552 | 99 | 2.17% | 36 | 0.79% | 3 | 3.03% | 0 | 0.00% | 0 | 0.00% |
| SC125nor | 3090 | 62 | 2.01% | 21 | 0.68% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
| SC2ssc | 1608 | 10 | 0.62% | 4 | 0.25% | 0 | 0.00% | 1 | 10.00% | 0 | 0.00% |
| SC5ssc | 4120 | 158 | 3.83% | 100 | 2.43% | 2 | 1.27% | 11 | 6.96% | 1 | 0.63% |
| SC19ssc | 1920 | 127 | 6.61% | 51 | 2.66% | 4 | 3.15% | 12 | 9.45% | 0 | 0.00% |
| SC49ssc | 3091 | 15 | 0.49% | 1 | 0.03% | 0 | 0.00% | 2 | 13.33% | 0 | 0.00% |
| SC60ssc | 1785 | 38 | 2.13% | 10 | 0.56% | 0 | 0.00% | 10 | 26.32% | 0 | 0.00% |
| SC69ssc | 2407 | 169 | 7.02% | 79 | 3.28% | 44 | 26.04% | 11 | 6.51% | 1 | 0.59% |
| SC70ssc | 2714 | 25 | 0.92% | 9 | 0.33% | 0 | 0.00% | 4 | 16.00% | 0 | 0.00% |
| SC86ssc | 3663 | 88 | 2.40% | 31 | 0.85% | 1 | 1.14% | 2 | 2.27% | 0 | 0.00% |
| SC119ssc | 4696 | 35 | 0.75% | 12 | 0.26% | 0 | 0.00% | 1 | 2.86% | 1 | 2.86% |
| SC185ssc | 3443 | 262 | 7.61% | 124 | 3.60% | 2 | 0.76% | 5 | 1.91% | 0 | 0.00% |
| SC188ssc | 3993 | 219 | 5.48% | 88 | 2.20% | 2 | 0.91% | 59 | 26.94% | 13 | 5.94% |
| SC189ssc | 3543 | 482 | 13.60% | 267 | 7.54% | 155 | 32.16% | 68 | 14.11% | 10 | 2.07% |
| Mean of HC | 2822 | 84 | 2.98% | 35 | 1.24% | 1 | 1.19% | 2 | 2.38% | 0 | 0.00% |
| Mean of SSc | 3082 | 136 | 4.41% | 65 | 2.11% | 18 | 13.24% | 16 | 11.76% | 2 | 1.47% |
| p-value (Wilcoxon test)A | 0.3139 | 0.3857 | 0.4614 | 0.404 | 0.4106 | 0.3342 | 0.416 | 0.0048 | 0.001 | 0.0831 | 0.0654 |
A:
The P-values were calculated based on the number or percentage of cells in different subpopulation from HC/SSc samples.