Skip to main content
. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Clin Cancer Res. 2021 Oct 1;27(19):5168–5187. doi: 10.1158/1078-0432.CCR-21-1259

Table 2:

Adjuvant RT for FA-HNSCC Primaries

Patient Age Sex FA Group SCT (Age) Tumor site (subsite) Stage RT Dose Toxicities Interruption or Termination of RT Outcome Recurrence Second Primary
Anak #1 (2020)106 15 M NA Yes Oral cavity (retromolar trigone) T3N1M0 42.5 Gy total (in 25 fractions) Mucositis, wound site breakdown, cerebral edema, somnolence Yes (terminated) DOD (6 mo pD) - -
Beckham #6 (2019)65 29 F C Yes Oral cavity (tongue) T2N1 66 Gy total to oral cavity (in 33 fractions), 50.4 Gy total to bilateral neck Mucositis (grade 2), dermatitis (grade 2) No DOD (13 mo pD, 12 mo pS, 9 mo pRT) Yes -
Nolan 2017100 31 M NA Yes (12) Oral cavity (buccal mucosa) NA Dose NA NA No DOD (9 yr pD) Yes* [Table 7] -
Kutler #10 (2016)4 48.5 M J No Oral cavity (retromolar trigone) T4N2bM0 40 Gy total (200 cGy x20 fractions) over 33 days Mucositis (high grade), dysphagia, cytopenia, sepsis Yes DOD (10 mo pS) - -
Kutler #1 (2016)4 30.2 F A No Oral cavity (buccal gingiva) T4N0M0 25 Gy total Sepsis Yes DOD (16 mo pS) Yes -
Kutler #18 (2016)4 43.9 M A No Oral cavity (alveolus) T4N2bM0 61 Gy total over 55 days Mucositis (high grade), cytopenia, graft site breakdown, mandibular hardware removal No DOD (172 mo pS) Yes -
Kutler #17 (2016)4 36.9 F A No Oral cavity (alveolus) T4N1M0 56 Gy total Mucositis (high grade), dysphagia, cytopenia, hemorrhage, pleural thickening, sepsis No DOD (171 mo pS) - -
Kutler #20 (2016)4 26.8 F C Yes Oral cavity (submandibular) T4N2cM0 Dose NA Dysphagia, dyspnea, cardiac arrest Yes DOD (20 mo pS) - -
Kutler #12 (2016)4 42.1 F A No Oral cavity (alveolus) T4N2bM0 64.6 Gy total (170 cGy x30 fractions) over 70 days Dysphagia, cytopenia No DOD (113 pS) - -
Kutler #30 (2016)4 41.1 F A No NA TXN2bM0 60 Gy total (200 cGy x30 fractions) over 39 days Mucositis (high grade), dysphagia, cytopenia, hemorrhage, trismus, xerostomia, fibrosis, esophageal stenosis No NED (178 mo pS) - -
Kutler #9 (2016)4 20.9 M P No Oral cavity (tongue) T4N2cM0 70.2 Gy total (180 cGy x39 fractions) over 50 days Mucositis (high grade), dermatitis, cytopenia, sepsis No DOD (34 mo pS) - -
Kutler #2 (2016)4 42.1 M A Yes Larynx (supraglottis) T2N2bM0 55.8 Gy total (180 cGy x22 fractions) over 31 days Mucositis (high grade), dysphagia, laryngeal edema, fibrosis, esophageal stenosis No DOD (341 mo pS) Yes -
Kutler #33 (2016)4 29 F C Yes Oral cavity (tongue) T2N1M0 50 Gy total (200 cGy x25 fractions) over 31 days Trismus, erythema No DOD (31 mo pS) - -
Kutler #34 (2016)4 44 F A No Oral cavity (tongue) T1N0M0 25 Gy total Erythema No DOD (73 mo pS) - -
Bonfim #4 (2016)84 24 M NA Yes Oral cavity T4aN2M0 Dose NA NA NA AWD (NA) - -
Bonfim #8 (2016)84 12 F NA Yes Oral cavity T2N0M0 Dose NA NA NA DOD (NA) - -
Kaplan 201187 43 F NA NA Oral cavity (floor of mouth) NA Dose NA NA No NED (19 mo pS) - Pharynx
Chao 2010117 43 F NA NA Oral cavity (floor of mouth, mandible) NA Dose NA NA Ongoing NED (4 mo pS) - -
Masserot #2 (2008)64 16.9 M NA Yes (11.2) Oral cavity (tongue) T2N+M0 22 Gy total NA Yes DOD (5.5 mo pD) - -
Bremer #2 (2003)49 32 M NA No Pharynx (lateral and posterior oropharyngeal wall) T4cN2M0 8 Gy total (100 cGy x5 fractions, 150 cGy x2 fractions) Thrombocytopenia (grade 5) Yes (terminated) DOD (NA) - -
Kozhevnikov 1986118 14 M NA No Oral cavity (gingiva) T3N0M0 80 Gy total Local bleeding NA DOD (6 mo pRT) - -
Esparza 196695 26 F NA No Esophagus (middle) NA Dose NA NA NA DOD (4 mo pRT) - -