Table 3:
Primary RT for FA-HNSCC Primaries
| Patient | Age | Sex | FA Group | SCT (Age) | Tumor site (subsite) | Stage | RT Dose | Toxicities | Interruption or Termination of RT | Outcome | Recurrence | Second Primary |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anak #4 (2020)106 | 32 | F | NA | Yes | Esophagus (middle third) | T2N0M0 | 45.9 Gy total (in 27 fractions) | Mucositis, dysphagia, retrosternal pain, pneumonitis, esophageal stenosis | No | DOD (10 mo pD, 3 mo pRT) | - | Oral cavity |
| Lach #2 (2020)48 | 52 | M | A | No | Larynx | T2N0M0 | 69 Gy total | NA | No | Died of SP (esophagus) | - | Esophagus, Anus |
| Budrukkar 2009101 | 27 | M | NA | No | Pharynx (BOT) | T2N0M0 | 70 Gy total (200 cGy x35 fractions) over 51 days | Mucositis (grade 3), dermatitis (grade 3), leukopenia with fever | No | AWD (14 mo pD) | Yes | - |
| Han 200996 | 32 | F | NA | No | Oral cavity (retromolar trigone and hard palate), HPV+ | NA | [IMRT] 64.8 Gy total (in 27 fractions) | Mucositis (grade 3), leukopenia (grade 4) | No | DOD (NA) | - | Vulva, cervix |
| Masserot #6 (2008)64 | 19.7 | M | NA | Yes (7.3) | Pharynx (oropharynx) | T4N2cMX | 70 Gy total | Mucositis (grade 3), severe dehydration | No | DOD (4.5 mo pD) | - | - |
| Masserot #8 (2008)64 | 10.1 | M | NA | Yes (4.6) | Oral cavity (tongue) | T3N0MX | 25 Gy total over 4 weeks (vs. 65 Gy planned) | Mucositis (severe) | Yes (terminated) | DOD (2.5 mo pD) | - | - |
| Horta 2006119 | 24 | F | NA | No | Pharynx (pyriform sinus) | NA | 19.8 Gy total | Dysphagia, odynophagia, neutropenia, pneumonia | Yes (terminated) | DOD (NA) | - | - |
| Marcou 2001102 | 32 | F | A | No | Pharynx (tonsil) | NA | 34 Gy total in 17 fractions (vs. 60 Gy planned) | Mucositis, ulceration, dysphagia, septicemia | Yes (terminated) | AWD (2 mo pRT) | - | - |
| Kozarek 1981120 | 26 | M | NA | No | Esophagus (cervical) | NA | 70 Gy total | Laryngeal edema, pneumonia | Yes (died during RT) | DOD (during RT) | - | - |