Table 1.
Multivariate linear regression analysis output for variables independently associated with IgA, IgG and IgM on day 1
| Variable | B | 95% CI | p |
|---|---|---|---|
| IgA | |||
| Female sex | − 34.1 | − 47.5: − 20.7 | 7.0 × 10–7 |
| BMI | 2.6 | 1.4: 3.8 | 1.5 × 10–5 |
| White blood cell count at baseline | 1.4 | 0.7: 2.1 | 6.0 × 10–5 |
| CV comorbidities | 28.6 | 11.2: 46.1 | 0.001 |
| Randomized to crystalloids | 19.4 | 6.3: 32.5 | 0.004 |
| Onco-haematologic disease | − 48.0 | − 87.0: − 9.1 | 0.016 |
| Creatinine | − 3.5 | − 7.6: 0.6 | 0.090 |
| Immunocompromised state | − 18.3 | − 40.0: 3.3 | 0.097 |
| IgG | |||
| Female sex | − 88.5 | − 135.5: − 41.4 | 2.4 × 10–4 |
| White blood cell count at baseline | 4.2 | 1.7: 6.6 | 0.001 |
| Randomized to crystalloids | 73.7 | 27.5: 120.0 | 0.002 |
| BMI | 5.8 | 1.7: 10.0 | 0.006 |
| Shock | − 55.1 | − 101.8: − 8.4 | 0.021 |
| Liver disease | 188.5 | − 3.5: 380.4 | 0.054 |
| Heart rate | − 0.9 | − 2.0: 0.3 | 0.127 |
| Immunocompromised state | − 9.3 | − 79.1: 60.6 | 0.794 |
| IgM | |||
| Age | − 0.6 | − 0.9: − 0.2 | 0.002 |
| Shock | − 14.4 | − 25.3: − 3.6 | 0.009 |
| Onco-haematologic disease | − 30.1 | − 58.2: − 2.0 | 0.036 |
| White blood cell count at baseline | 0.4 | − 0.1: 1.0 | 0.127 |
| Mean arterial pressure | 0.2 | − 0.2: 0.5 | 0.329 |
Output for multivariable linear regression analysis with continuous Ig concentration as dependent variable
Included in the regression analyses are the variables which were significant in Additional file 1: Tables S1, S2 and S3. For IgG, AIDS was not included due to confounding by immuno-compromised state. Location of infection was not included in this analysis