Table 4.
Predictive performances of single versus combined hematological parameters in identifying patients with rheumatoid arthritis remission.
| Hematological parameter |
Sensitivity (%) |
Specificity (%) |
PPV (%) |
NPV (%) |
AUC |
|---|---|---|---|---|---|
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | |
| Hb level ≥12.2 g/dL for women and ≥12.4 g/dL for men | 61.9 (51.9–71.1) | 69.5 (62.9–75.5) | 49.2 (40.5–58.0) | 79.3 (72.7–84.6) | 0.657 (0.593–0.722) |
| NLR ≤2.6 | 75.2 (65.7–82.9) | 43.2 (36.6–50.0) | 38.7 (32.1–45.8) | 78.5 (69.9–85.2) | 0.592 (0.527–0.657) |
| MPV ≥8.4 fL | 48.6 (38.8–58.5) | 69.5 (62.9–75.5) | 43.2 (34.2–52.7) | 73.9 (67.3–79.6) | 0.591 (0.524–0.658) |
| Combination of Hb level and NLRa | 91.4 (83.9–95.8) | 30.5 (24.5–37.1) | 38.6 (32.5–44.9) | 88.2 (78.2–94.1) | 0.609 (0.547–0.672) |
| Combination of Hb level and MPVb | 81.0 (71.9–87.7) | 48.2 (41.4–55.0) | 42.7 (35.8–49.9) | 84.1 (76.3–89.8) | 0.646 (0.584–0.708) |
| Combination of NLR and MPVc | 84.8 (76.1–90.8) | 33.2 (27.1–39.9) | 37.7 (31.6–44.3) | 82.0 (72.1–89.1) | 0.590 (0.526–0.654) |
| Combination of Hb level, NLR and MPVd | 95.2 (88.7–98.2) | 23.6 (18.3–29.9) | 37.3 (31.6–43.4) | 91.2 (80.0–96.7) | 0.594 (0.532–0.657) |
AUC, area under the receiver operating characteristic curve; CI, confidence interval; Hb, hemoglobin; MPV, mean platelet volume; NLR, neutrophil-to-lymphocyte ratio; NPV, negative predictive value; PPV, positive predictive value.
a
Either Hb level ≥ cutoff point (≥12.2 g/dL for women and ≥12.4 g/dL for men) or NLR ≤2.6.
b
Either Hb level ≥ cutoff point (≥12.2 g/dL for women and ≥12.4 g/dL for men) or MPV ≥8.4 fL.
c
Either NLR ≤2.6 or MPV ≥8.4 fL.
d
Hb level ≥ cutoff point (≥12.2 g/dL for women and ≥12.4 g/dL for men) or NLR ≤2.6 or MPV ≥8.4 fL.