Table 2.
Reference intervals for white blood cells
| Cell type | Non-pregnant 95% reference intervals [14](×109/L) | Parametric pregnancy-specific 95% reference intervals*(×109/L) | Non-parametric pregnancy-specific 95% reference intervals⁎⁎ (×109/L) |
|
|---|---|---|---|---|
| 2.5th centile (90% CI) | 97.5th centile (90% CI) | |||
| Total white blood cells | 4.0-11.0 | 5.7-15.0 | 5.7 (5.6-5.7) | 15.0 (14.9-15.1) |
| Neutrophils | 2.0-7.5 | 3.7-11.6 | 3.7 (3.6-3.7) | 11.6 (11.5-11.7) |
| Lymphocytes | 1.0-4.5 | 1.0-2.9 | 1.0 (1.0-1.0) | 2.9 (2.9-3.0) |
| Eosinophils | 0.04-0.44 | 0.02-0.39 | 0.02 (0.02-0.02) | 0.39 (0.39-0.40) |
| Basophils | 0.0-0.1 | 0.1-0.1 | 0.0 (0.0-0.0) | 0.1 (0.1-0.1) |
| Monocytes | 0.2-0.8 | 0.3-1.1 | 0.3 (0.3-0.3) | 1.1 (1.1-1.1) |
⁎
Parametric RIs were estimated as the mean ± 1.96 multiples of the standard deviation, using logarithmically transformed data between 8-40 weeks.
⁎⁎
For reference, conventional non-parametric reference intervals are presented with 90% confidence intervals, in accordance with CLSI/IFCC guidance,12 showing strong concordance between the two methods.