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. 2021 Oct 26;41(11):1195–1227. doi: 10.1002/cac2.12218
Content Basic principles
Position immobilization Head, neck, and shoulder thermoplastic film + individualized Styrofoam head and neck cushion (recommended); head, neck, and shoulder thermoplastic film + head, neck and shoulder vacuum bag; head, neck, and shoulder thermoplastic film + water‐activated fixed pillow; head, neck, and shoulder thermoplastic film + standard resin headrest.
CT localization The scanning position is the head‐first supine position. The scanning and reconstruction layer thickness is 3 mm. The scanning method is a 140 KV plain scan + 120 KV enhanced scan. Field of view includes the space sufficient to cover the widest part of the patient's shoulder.
MRI localization The scanning position is the head‐first supine position. The scanning sequence is T1, T2, T1 enhancement, and T1 fat compression enhancement. The scanning layer thickness is 3 mm, layer spacing is 0 mm, and the scanning method is plain scanning + enhanced scanning.
Planning and design IMRT reverse plan design is recommended for nasopharyngeal carcinoma radiotherapy plan. The fixed‐beam IMRT method is usually used, and the irradiation field is ≥ 5 beams, which are uniformly distributed in the same plane. Single arc or double arc VMAT can also be used. The weight or intensity of each subfield is adjusted through the inverse optimization process, such that the high‐dose distribution is highly conformed to the contour of the tumor target area in the three‐dimensional direction.
Plan validation The content of IMRT dose verification should include point dose verification and dose distribution verification, and three‐dimensional dose verification, based on the patient's anatomy, is encouraged. The plan verification suggests that the actual gantry angle measurement and the multi‐angle synthetic dose verification method are optimized, and the absolute dose mode should be used to analyze the results. It is recommended to use global normalization to calculate the Gamma pass rate. Its tolerance limit: 3%/2 mm, 10% dose threshold, Gamma pass rate ≥ 95%; intervention limit: 3%/2 mm, 10% dose threshold, Gamma pass rate≥ 90%.
IGRT Before treatment, at least 2D IGRT technology must be used to verify the patient's positioning. If possible, medical institutions can use kV or MV CBCT, MRI, and other imaging technologies to implement daily image guidance during high‐precision radiotherapy.

Abbreviations: CBCT, cone‐beam CT; CT, computed tomography; IGRT, image‐guided radiotherapy; IMRT, intensity‐modulated radiotherapy; MRI, magnetic resonance imaging; VMAT, volumetric‐modulated arc therapy.