Fig. 3.

Pharmacokinetics of NP10679 in mouse. (A) Total plasma levels of NP10679 after a 10 mg/kg oral dose (black symbols) and a 3 mg/kg i.v. dose (open symbols) in mice are plotted. (B) Free plasma levels of NP10679 after a 2 mg/kg (open symbols) and a 5 mg/kg i.p. (black symbols) dose in mice are given. For (A) and (B), data are means ± S.E.M. (n = 3 per data point). The gray dashed line indicates the IC₅₀ of NP10679 for pH 6.9 inhibition of GluN2B receptors, the green dashed line is the functional IC₅₀ at H₁ histamine receptors, and the blue dashed line is the functional IC₅₀ at hERG potassium channels.