Fig. 6.
Salbutamol enters the β2-AR binding site through a novel polar channel. (A) From within the membrane view of the channel entrance (in yellow color and surface representation) displaying critical polar residues (in green color and licorice representation) that make immediate interactions with salbutamol (in blue color and licorice representation) as it enters. (B) The top view of the polar channel illustrating its position that is distal to the common access path lined by F193ECL2. (C and D) The snapshots show the intermediate states of salbutamol before reaching the binding pocket in its final bound pose, as presented in Fig. 6D. The receptor is illustrated in secondary structure representation (white).