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. 2021 Nov 27;16:169. doi: 10.1186/s11671-021-03626-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cytotoxicity of FePO₄-DOX NPs. a, b Cytotoxicity of Free Doxorubicin (DOX) and FePO₄-DOX NPs in mouse fibroblast NIH/3T3 and osteosarcoma K7M2 cell-line, respectively, at various DOX equivalent concentration. Cytotoxicity was analyzed in percentage cell viability after particle treatment for 48 h. c, d A comparison in percentage cell viability of FePO₄-DOX NPs and Free DOX in NIH/3T3 and K7M2 cell lines, respectively, at equivalent DOX concentration. The inset in the middle represents the IC-50 values of Free DOX and FePO₄-DOX NPs in NIH/3T3 and K7M2 cells (data represents mean ± s.d.; n = 6 replicates)