Table 1.
Summarized Donor Screening Recommendations
| Initial Screening | Essential information and health questionnaire |
|---|---|
| Inclusion Criteria | a40 ≥ Age ≥ 18 |
| Body mass index (< 28 or > 18.5 kg/m2) | |
| Providing informed consent | |
| Keeping honesty and self-discipline | |
| Feeling well at the period of donation | |
| Children may donate with parental consent and child’s assent | |
| Exclusion Criteria | High-risk behaviors |
| Sexual practices associated with high risk of acquiring infectious diseases in last 12 months | |
| Known exposure with HIV, HAV, HBV, HCV infection in the last 12 months | |
| Intravenous drug use, incarceration, tattoo, piercing within previous 6 months | |
| Risk factors for variant Cruetzfeldt-Jakob disease | |
| Communicable disease | |
| History of HIV, HAV, HBV or HCV infection | |
| Any of the following in the previous 4 weeks: fever, vomiting, diarrhea or other symptoms of infection | |
| Any of the following in the previous 8 weeks: vaccinations, injections or contact with a recipient of the smallpox vaccine | |
| Any of the following in the previous 12 months: blood transfusion, accidental needle stick or blood exposure | |
| Travel within previous 6 months to areas of high risk of travelers’ diarrhea | |
| Close contacts with active gastrointestinal infection | |
| General medical illness or use of medication | |
| Social history (e.g., smoking, drinking, etc.) | |
| Receipt of antibiotics or PPI in the previous 3 months | |
| Using of medications (e.g., an experimental medicine, immunomodulatory therapy, chemotherapy, etc.) | |
| History of intrinsic gastrointestinal disease (e.g., inflammatory bowel disease, irritable bowel syndrome, chronic constipation, gastrointestinal malignancy, prior major gastrointestinal surgery, procedure, etc.) | |
| Strong family history of colorectal cancer | |
| Disease history (e.g., malignancy, malnutrition, chronic pain syndromes, neurologic or neurodevelopmental disorders, autoimmune or atopic illness, cardiovascular/metabolic disease, diabetes, hypertension, stroke, mental diseases, etc.) | |
| aOral diseases (Caries, periodontal diseases, mucosal diseases or oral cancer) | |
| Others | |
| aHamilton Anxiety Rating Scale (> 7 score), Hamilton Depression Rating Scale (> 7 score) | |
| aLifestyle questionnaire survey (almost never exercise) | |
| Logistics issue (e.g., unable to donate regularly, distance to donor facility) | |
| Restrictive diet (e.g., gluten free diet) | |
| Abnormal vital sign (e.g., unexplained syncope) | |
| Gastrointestinal pathogens testing | Routine tests |
| Stool microscopy and culture, fecal occult blood test | |
| Intestinal parasites | |
| Fecal egg, cyst, microsporidia and parasites, Blastocystis hominis, Strongyloides stercoralis, Cyclospora, Isospora, Giardia, Cryptosporidium | |
| Intestinal pathogenic virus | |
| Rotavirus, Norovirus, Adenovirus | |
| Gastrointestinal pathogenic bacteria | |
| Helicobacter pylori, C. difficile, Entamoeba, Shiga toxin with reflex to O157, Salmonella/Shigella, Vibrio cholera O1 and O139, Listeria monocytogenes, Escherichia coli O157 H7, Yersinia, Campylobacter | |
| Intestinal drug-resistance bacteria | |
| Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci, Carbapenem-Resistant Enterobacteriaceae, Extended-Spectrum β-Lactamases bacteria | |
| Blood testing | Routine tests |
| Complete blood count, Liver function test, Renal function test, Blood glucose, Elevated C-Reactive Protein levels, Elevated dynamic ESR | |
| aLipidemia test | |
| Infectious pathogen | |
| Treponema pallidum serology | |
| HTLV I/II, HAV, HBV, HCV, HEV, HIV | |
| aSARS-CoV-2 virus |
aNew recommendations