Comparison 1. Enalapril versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Development of clinical heart failure	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.16 [0.02, 1.29]
2 Dizziness or hypotension	1	135	Risk Ratio (M‐H, Random, 95% CI)	7.17 [1.71, 30.17]
3 Rash or hives	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.25, 3.67]
4 Heart palpitations	1	135	Risk Ratio (M‐H, Random, 95% CI)	3.83 [0.44, 33.35]
5 Anxiety or depression	1	135	Risk Ratio (M‐H, Random, 95% CI)	1.91 [0.18, 20.60]
6 Headache	1	135	Risk Ratio (M‐H, Random, 95% CI)	3.83 [0.44, 33.35]
7 Gastrointestinal disturbance	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.20, 4.57]
8 Hepatitis C	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.64 [0.11, 3.70]
9 Neutropenia	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.48 [0.04, 5.15]
10 Musculoskeletal pain	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.20, 4.57]
11 Dry cough	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.06, 14.98]
12 Shortness of breath	1	135	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.14, 6.59]
13 Chest pain	1	135	Risk Ratio (M‐H, Random, 95% CI)	1.67 [0.51, 5.45]