Table 1.

Predictive factors of publication in high-impact general journals in the derivation cohort, compared to high-impact critical care journals

Characteristic a		Total (%) (n = 510)	Univariate analysis					Multivariate analysis
			OR		95%CI	P value		OR	95%CI		P value
Sample size	< 46	107 (21%)	1					1
	46–120	141 (27%)	3.58		0.76–16.92	0.11		3.00	0.57–15.68		0.19
	121–352	137 (27%)	15.35		3.58–65.77	< 0.001		8.56	1.72–42.68		0.01
	> 352	125 (25%)	120.17		28.19–512.23	< 0.001		61.09	11.51–324.22		< 0.001
Number of centers	1	258 (50%)	1					1
	2–10	117 (23%)	4.74		2.55–8.79	< 0.001		1.84	0.84–4.02		0.13
	> 10	135 (27%)	17.21		9.65–30.70	< 0.001		3.28	1.43–7.54		0.01
International trial	Yes / No	76 (15%) / 434 (85%)	4.93		2.96–8.20	< 0.001		1.76	0.84–3.66		0.13
Primary endpoint	Mortality alone	93 (18%)	8.66		2.26–14.24	< 0.001		3.87	1.92–7.79		0.002
	Composite including mortality	16 (3%)	9.11		3.20–25.98	< 0.001		12.91	3.14–53.01		0.004
	Other	401 (79%)	1					1
Interpretation result	Significant for benefit	233 (46%)	0.42		0.27–0.64	< 0.001		1.28	0.70–2.35		0.43
	Significant for harm	6 (1%)	1.04		0.19–5.79	0.96		0.38	0.04–3.40		0.38
	Unsignificant	271 (53%)	1					1
Type of intervention	Drug (Yes/No)	213 (42%) / 297 (58%)	0.71		0.48–1.06	0.10		0.80	0.43–1.49		0.48
Country of first author	USA (Yes/No)	111 (22%) / 399 (78%)	1.34		0.84–2.13	0.53		1.31	0.69–2.48		0.41
Topic	Sepsis	84 (17%)	1					1
	Cardiovascular	89 (18%)	1.62		0.81–3.28	0.17		1.26	0.47–3.43		0.64
	Ventilation	130 (25%)	1.29		0.66–2.50	0.45		6.27	2.30–17.11		< 0.001
	Miscellaneous	207 (40%)	1.39		0.75–2.58	0.29		5.10	2.02–12.89		< 0.001

OR: Odd Ratio, 95%CI: Confidence Interval at 95%, USA: United States of America

^a There was no missing data in the derivation cohort