TABLE 2.

The effect of top-ranking 40 compounds from NCI DTP on catalytic activity of recombinant rat Nln

Mean values from two independent experiments are shown. Structures and additional physicochemical information for these compounds can be found at https://dtp.cancer.gov/dtpstandard/dwindex/index.jsp based on their NSC number.

NSC #	608820	615399	639022	640354	659264	296961	302851	332636	333568	339919
Score ranking	13, 41, 44	34	54	32	49	48	10, 27, 56	46	23, 37	57
% activity at 10 µMa	102	108	91	79	104	106	104	103	106	100
% activity at 100 µMa	108	108	30	76	107	127	80	64	77	63
NSC #	359097	374121	400844	523374	600947	353874	211002	266752	281707	282137
Score ranking	5	35	30	7, 9, 22, 71	11, 45, 89	2	15	59, 83	14	36
% activity at 10 µM	87	121	104	122	107	122	104	107	109	106
% activity at 100 µM	92	226	84	206	105	80	100	97	113	94
NSC #	343659	14541	15180	47096	134514	155877	163084	203396	210826	48778
Score ranking	20	6	42	43, 99	21, 25, 40, 47	8	12	16	53	18, 73
% activity at 10 µM	105	97	102	101	92	82	103	102	101	89
% activity at 100 µM	106	103	95	111	9	4	102	106	105	84
NSC #	82001	88659	89624	92597	121184	128977	131922	134119	340049	343028
Score ranking	17	50	19, 38	51, 64	24	3	26, 39, 55, 82	31	33, 52	28, 29
% activity at 10 µM	105	100	102	105	77	80	96	83	94	98
% activity at 100 µM	100	100	38	98	18	68	28	41	52	73

^aCompared with basal activity (i.e., vehicle control at 100%).