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. 2021 Sep;100(3):217–223. doi: 10.1124/molpharm.121.000249

Fig. 1.

Fig. 1.

Opioid agonist inhibition of evoked IPSCs is differentially affected in RGS-insensitive mice. (A) Representative traces depicting inhibition of eIPSCs by DAMGO (5 µM) in WT and RGS-insensitive (Het) mice. The inhibition is reversed by naloxone. (B) Combined experiments of % inhibition (±S.D.) by a maximal DAMGO concentration (20 µM; gray bar) and a submaximal concentration (5 µM) in WT compared with Het mice (one-way ANOVA; F(2, 25) = 4.9, P = 0.02; Dunnett’s, *P < 0.05). (C) Combined experiments of % inhibition (±S.D.) by a maximal ME concentration (30 µM; gray bar) and a submaximal concentration (10 µM) in WT compared with Het mice (one-way ANOVA; F(2, 15)= 17.7, P = 0.0001; Dunnett’s, *P < 0.05; ****P < 0.0001). (D) Combined experiments of % inhibition (±S.D.) by a maximal fentanyl concentration (10 µM; gray bar) and a submaximal concentration (1 µM) in WT compared with Het mice (one-way ANOVA; F(2, 18)= 4.1, P = 0.03; Dunnett’s, *P < 0.05). Symbols in bars denote recordings, and numbers denote number of animals used in each group.