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. 2021 Sep;100(3):217–223. doi: 10.1124/molpharm.121.000249

Fig. 2.

Fig. 2.

MOR agonists differentially activate Gα subunits to inhibit evoked GABA release. (A) DAMGO (5 µM)-mediated inhibition of eIPSCs in the absence (control) and presence of Gαo peptide inhibitor and Gαi peptide inhibitors (one-way ANOVA, F(3, 22) = 19.1, P = 0.0001; Dunnett’s, **P < 0.001, ****P < 0.0001). (B) ME (10 µM)-mediated inhibition of eIPSCs in absence and presence of inhibitors (one-way ANOVA, F(3, 19) = 4.2; P = 0.02; Dunnett’s, **P < 0.001). (C) Fentanyl (1 µM)-mediated inhibition of eIPSCs in absence and presence of inhibitors (one-way ANOVA, F(2, 14) = 7.3, P = 0.007, Dunnett’s, *P < 0.05, ** P < 0.001). Symbols in bars denote recordings, and numbers denote number of animals used in each bar. inhib, inhibitor; ns, not significant.