Fig. 5.
Baclofen-mediated inhibition of evoked GABA release is not affected in slices from RGS-insensitive mice or by Gαo/i peptide inhibitors. (A) Baclofen (5 µM) inhibition is similar in WT and RGS-insensitive (Het) mice (t(12) = 1.3, P = 0.2). (B) Baclofen (5 µM)-mediated inhibition is not altered in the presence of peptide inhibitors (F(3, 20) = 0.2, P = 0.9). (C) Baclofen (20 µM)-mediated inhibition is not altered by the peptide inhibitors (F(2, 24) = 0.3, P = 0.7). Symbols in bars denote recordings, and numbers denote number of animals used in each bar. inhib, inhibitor.