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. 2021 Oct;73(4):298–487. doi: 10.1124/pharmrev.120.000131

Fig. 46.

Fig. 46

Multiple binding poses for GluN2B-selective negative allosteric modulators. (A) Binding site for GluN2B-selective NAMs at the GluN1/2B NTD heterodimer interface. The structure is the hybrid from GluN1/2B heterotetramer (PDB: 6WHR) and GluN1/2B NTD heterodimer (PDB: 6E7U). (B) Binding poses for different GluN2B-selective NAMs show occupancy of each arm or both arms of the binding pocket at the interface between the GluN1/2B NTD heterodimer (PDB: 3QEL, 5EWM, 6E7U for ifenprodil-, EVT-101-, and EU93-31–bound structures). (C) The proposed binding site for the GluN2C-selective PAM PYD-106 is shown at the interface between the GluN2C NTD and ABD in a model from Kaiser et al. (2018).